My rule of thumb:
When you see a good opportunity, jump.
There's no bigger crime than taking the things that could bring happiness or possibility into your life for granted.
See all those people sitting with their hand over their eyes, contemplating? Sitting next to them is the shovel they've been using to dig their own graves.
Is that a desirable alternative?
Then stop being an idiot.
Dream big. And when you meet your dream on a crowded street, grab it before it disappears into the crowd to fulfill someone else.